After the tragic loss of his wife battling the forces of darkness, Gabriel is persuaded to rejoin his former team of demon hunters traveling from relatively obscurity in America to the deep unknown regions of Europe. He is joined by his estranged best friend Michael who harbors a dark secret, the mystical Hannah whose visions predict the future, and a motley crew of demon slayers. After losing part of his team Gabriel must confront his tragic past and decide who really is friend or foe.

After he's attacked on the street at night by a roving motorcycle gang, timid bookkeeper Casey (Jesse Eisenberg) joins a neighborhood karate studio to learn how to protect himself. Under the watchful eye of a charismatic instructor, Sensei (Alessandro Nivola), and hardcore brown belt Anna (Imogen Poots), Casey gains a newfound sense of confidence for the first time in his life. But when he attends Sensei's mysterious night classes, he discovers a sinister world of fraternity, brutality and...